Immune therapy using optimal control with L1 type objective

@article{Bara2016ImmuneTU,
  title={Immune therapy using optimal control with L1 type objective},
  author={Ouassim Bara and Seddik M. Djouadi and Judy Day},
  journal={2016 American Control Conference (ACC)},
  year={2016},
  pages={4895-4900}
}
Treatment of pathogenic infection is formulated as an optimal control problem with an L1 type objective. Being unable to regulate the resulting inflammatory response can be detrimental for the affected patient. A strategy given by a pro-inflammatory and anti-inflammatory mediator drug treatment is derived. We apply maximum principle and the optimality system composed of four differential equation and their corresponding adjoint equations are solved numerically. Simulation results are discussed… CONTINUE READING

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