Immune therapy in type 1 diabetes mellitus

@article{Lernmark2013ImmuneTI,
  title={Immune therapy in type 1 diabetes mellitus},
  author={{\AA}. Lernmark and H. Larsson},
  journal={Nature Reviews Endocrinology},
  year={2013},
  volume={9},
  pages={92-103}
}
  • Å. Lernmark, H. Larsson
  • Published 2013
  • Medicine
  • Nature Reviews Endocrinology
  • Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and unknown environmental triggers. In most countries, only 10–15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. Autoantibodies against insulin, GAD65, IA-2 or the ZnT8 transporter mark islet autoimmunity. These islet autoantibodies may already have developed in… CONTINUE READING
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    References

    SHOWING 1-10 OF 102 REFERENCES
    Autoantibodies in diabetes.
    • 151
    • PDF
    T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives
    • 64
    • PDF
    Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).
    • 308
    • PDF