Immune therapy in type 1 diabetes mellitus
@article{Lernmark2013ImmuneTI,
title={Immune therapy in type 1 diabetes mellitus},
author={{\AA}. Lernmark and H. Larsson},
journal={Nature Reviews Endocrinology},
year={2013},
volume={9},
pages={92-103}
}Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and unknown environmental triggers. In most countries, only 10–15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. Autoantibodies against insulin, GAD65, IA-2 or the ZnT8 transporter mark islet autoimmunity. These islet autoantibodies may already have developed in… CONTINUE READING
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