Immune therapy in type 1 diabetes mellitus

  title={Immune therapy in type 1 diabetes mellitus},
  author={{\AA}. Lernmark and H. Larsson},
  journal={Nature Reviews Endocrinology},
  • Å. Lernmark, H. Larsson
  • Published 2013
  • Medicine
  • Nature Reviews Endocrinology
  • Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and unknown environmental triggers. In most countries, only 10–15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. Autoantibodies against insulin, GAD65, IA-2 or the ZnT8 transporter mark islet autoimmunity. These islet autoantibodies may already have developed in… CONTINUE READING
    81 Citations
    Advances in immunotherapy of type I diabetes.
    • 10
    Depleting T Cells in Newly Diagnosed Autoimmune (Type 1) Diabetes—Are We Getting Anywhere?
    • 2
    • PDF
    Risk Factors and Primary Prevention Trials for Type 1 Diabetes
    • 26
    • PDF


    Autoantibodies in diabetes.
    • 153
    • PDF
    T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives
    • 65
    • PDF
    Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).
    • 310
    • PDF