Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

@inproceedings{Tran2013ImmuneTO,
  title={Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia},
  author={Eric Tran and Dhanalakshmi Chinnasamy and Zhiya Yu and Richard A. Morgan and Chyi-chia Lee and Nicholas P Restifo and Steven A Rosenberg},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Fibroblast activation protein (FAP) is a candidate universal target antigen because it has been reported to be selectively expressed in nearly all solid tumors by a subset of immunosuppressive tumor stromal fibroblasts. We verified that 18/18 human tumors of various histologies contained pronounced stromal elements staining strongly for FAP, and hypothesized that targeting tumor stroma with FAP-reactive T cells would inhibit tumor growth in cancer-bearing hosts. T cells genetically engineered… CONTINUE READING