Immune system learning and memory quantified by graphical analysis of B-lymphocyte phylogenetic trees.

@article{DunnWalters2004ImmuneSL,
  title={Immune system learning and memory quantified by graphical analysis of B-lymphocyte phylogenetic trees.},
  author={Deborah Dunn-Walters and Hanna Edelman and Ramit Mehr},
  journal={Bio Systems},
  year={2004},
  volume={76 1-3},
  pages={141-55}
}
The immune system learns from its encounters with pathogens and memorizes its experiences. One of the mechanisms it uses for this purpose is the intra-individual evolution of antigen receptors on B lymphocytes, achieved via hypermutation and selection of antigen receptor variable region genes during an immune response. We have developed a novel method for analyzing the graphical properties of phylogenetic trees of receptor genes which have been mutated and selected during an immune response. In… CONTINUE READING