Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis

@article{Menon2004ImmuneSA,
  title={Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis},
  author={Anand G. Menon and Connie M Janssen - van Rhijn and Hans Morreau and Hein Putter and Rob A. E. M. Tollenaar and Cornelis J. H. van de Velde and Gert Jan J Fleuren and Peter J K Kuppen},
  journal={Laboratory Investigation},
  year={2004},
  volume={84},
  pages={493-501}
}
The efficacy of tumor cell–immune cell interactions depends on a number of factors, for example, the expression of HLA-I on tumor cells, the type of immune cell, the accessibility of tumor cells for immune cells and the expression of immunogenic epitopes. We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B… CONTINUE READING
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