Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?
- Psychology, MedicineTranslational Psychiatry
The novel concept of “autoimmune OCD” is proposed for a small subgroup of OCD patients, and clinical signs based on the PANDAS/PANS criteria and from recent experience with autoimmune encephalitis and autoimmune psychosis are suggested.
Obsessive-Compulsive Disorder With Rheumatological and Inflammatory Diseases: A Systematic Review
- Medicine, BiologyCureus
The pathophysiology and etiology of OCD are strongly correlated with inflammatory biomarkers, and this finding warrants future studies on the efficacy of anti-inflammatory agents to treat OCD, particularly in the early stages of the disease.
Immune Dysfunction in Obsessive-Compulsive Disorder: From Risk Factors to Multisystem Involvement
- Psychology, BiologyImmuno-Psychiatry
Evidence is reviewed supporting a model for immune dysfunction in OCD as multifactorial, constitutive, and environmental, contributing to illness development, clinical presentation, and multisystem impact.
Obsessive-compulsive disorder in children and adolescents: epidemiology, diagnosis and management.
- Psychology, MedicineTranslational pediatrics
Current concepts in OCD, including its epidemiology and etiologic underpinnings (behavioral, neurological, immunological, gastroenterological, as well as genetic), and the interplay of PANS and PANDAS are considered.
Searching for host immune-microbiome mechanisms in obsessive-compulsive disorder: A narrative literature review and future directions
- Biology, PsychologyNeuroscience & Biobehavioral Reviews
Association of antibody titers and 5-HTTLPR gene polymorphisms in pediatric autoimmune neuropsychiatric disorder associated with streptococci
- Biology, Medicine
The results suggest an association between the S allele and elevated antibody levels in PANDAS patients.
Plasma IL-6 levels in unmedicated, comorbidity free obsessive-compulsive disorder
- Psychology, MedicineInternational journal of psychiatry in clinical practice
Results in unmedicated and comorbidity-free OCD patients give a better understanding of the immune alterations in OCD, and plasma IL-6 levels did not correlate significantly with any clinical variables.
Obsessive compulsive disorder as a presenting symptom of COVID-19: A case-series from Iran
- Medicine, PsychologyCaspian journal of internal medicine
Obsessive compulsive symptoms can be the presenting manifestation of COVID-19 and the neuropsychiatric manifestations may be resulted from central nervous system infiltration, and dysregulation of inflammatory factors autoimmune responses.
Reduction in Obsessive Compulsive Disorder and Self-Injurious Behavior With Saccharomyces boulardii in a Child with Autism: A Case Report.
- Psychology, BiologyIntegrative medicine
Treatment with S boulardii successfully reduced OCD and SIB symptoms in this boy with autism spectrum disorder and self-injurious behavior.
Modulating neuroinflammation in COVID-19 patients with obsessive-compulsive disorder
- PsychologyJournal of Psychiatric Research
SHOWING 1-10 OF 100 REFERENCES
The cytokine profile of OCD: pathophysiological insights
- Psychology, Medicine
An exhaustive review of the role of the immune system in the development of OCD is presented, with a major focus on the possible pathophysiological role of cytokines that seems to open novel treatment.
Obsessive–compulsive disorder and immunology: A review
- Medicine, PsychologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
Immunological alterations in adult obsessive-compulsive disorder
- Medicine, BiologyBiological Psychiatry
Obsessive-Compulsive Disorder and Immunocompetence
- Psychology, MedicineInternational journal of psychiatry in medicine
Adult OCD patients appear to have an increased rate of immune-related diseases above and beyond that seen in other psychiatric disorders.
Tic disorders and obsessive-compulsive disorder: Is autoimmunity involved?
- Biology, MedicineInternational review of psychiatry
Future longitudinal studies should be aimed at assessing the precise relationship between symptom exacerbations, infections, and immune parameters, possibly along with gene expression profiles, to draw any firm conclusions about a role for autoimmunity.
The link between autoimmune diseases and obsessive-compulsive and tic disorders: A systematic review
- PsychologyNeuroscience & Biobehavioral Reviews
Searching for the Immune Basis of Obsessive-Compulsive Disorder
- Psychology, BiologyNeuroimmunomodulation
The assessment of circulating cytokines and immune cells confirmed unequivocal changes in at least some patients, although it is difficult to establish a particular immune profile in OCD.
Immunology of obsessive-compulsive disorder.
- Psychology, MedicineThe Psychiatric clinics of North America
Prevalence of anti-basal ganglia antibodies in adult obsessive-compulsive disorder: cross-sectional study.
- Medicine, PsychologyThe British journal of psychiatry : the journal of mental science
The hypothesis that central nervous system autoimmunity may have an aetiological role in some adults with OCD is supported and exposure to streptococcal infection in vulnerable individuals is a risk factor for the development of OCD.
The glutamate-based genetic immune hypothesis in obsessive-compulsive disorder. An integrative approach from genes to symptoms
- Biology, PsychologyNeuroscience