Immune system and obsessive-compulsive disorder

@article{Marazziti2018ImmuneSA,
  title={Immune system and obsessive-compulsive disorder},
  author={Donatella Marazziti and Federico Mucci and Leonardo Franklin Fontenelle},
  journal={Psychoneuroendocrinology},
  year={2018},
  volume={93},
  pages={39-44}
}
Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?
TLDR
The novel concept of “autoimmune OCD” is proposed for a small subgroup of OCD patients, and clinical signs based on the PANDAS/PANS criteria and from recent experience with autoimmune encephalitis and autoimmune psychosis are suggested.
Obsessive-Compulsive Disorder With Rheumatological and Inflammatory Diseases: A Systematic Review
TLDR
The pathophysiology and etiology of OCD are strongly correlated with inflammatory biomarkers, and this finding warrants future studies on the efficacy of anti-inflammatory agents to treat OCD, particularly in the early stages of the disease.
Immune Dysfunction in Obsessive-Compulsive Disorder: From Risk Factors to Multisystem Involvement
TLDR
Evidence is reviewed supporting a model for immune dysfunction in OCD as multifactorial, constitutive, and environmental, contributing to illness development, clinical presentation, and multisystem impact.
Obsessive-compulsive disorder in children and adolescents: epidemiology, diagnosis and management.
TLDR
Current concepts in OCD, including its epidemiology and etiologic underpinnings (behavioral, neurological, immunological, gastroenterological, as well as genetic), and the interplay of PANS and PANDAS are considered.
Association of antibody titers and 5-HTTLPR gene polymorphisms in pediatric autoimmune neuropsychiatric disorder associated with streptococci
TLDR
The results suggest an association between the S allele and elevated antibody levels in PANDAS patients.
Plasma IL-6 levels in unmedicated, comorbidity free obsessive-compulsive disorder
TLDR
Results in unmedicated and comorbidity-free OCD patients give a better understanding of the immune alterations in OCD, and plasma IL-6 levels did not correlate significantly with any clinical variables.
Obsessive compulsive disorder as a presenting symptom of COVID-19: A case-series from Iran
TLDR
Obsessive compulsive symptoms can be the presenting manifestation of COVID-19 and the neuropsychiatric manifestations may be resulted from central nervous system infiltration, and dysregulation of inflammatory factors autoimmune responses.
Reduction in Obsessive Compulsive Disorder and Self-Injurious Behavior With Saccharomyces boulardii in a Child with Autism: A Case Report.
TLDR
Treatment with S boulardii successfully reduced OCD and SIB symptoms in this boy with autism spectrum disorder and self-injurious behavior.
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