Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies.


Cellular senescence, a state of stable growth arrest, can occur in response to various stress stimuli such as telomere shortening, treatment with chemotherapeutic drugs or the aberrant activation of oncogenes. Senescent cells communicate with their environment by secreting various cytokines and growth factors, and it has become clear that this 'secretory… (More)
DOI: 10.1093/carcin/bgs124

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