Immune surveillance and antigen conformation determines humoral immune response to the prion protein immunogen.

@article{Rubenstein1999ImmuneSA,
  title={Immune surveillance and antigen conformation determines humoral immune response to the prion protein immunogen.},
  author={Richard Rubenstein and Richard J. Kascsak and Manuela Papini and Richard I. Carp and Giuseppe Lafauci and Rob Meloen and Jan Langeveld},
  journal={Journal of neurovirology},
  year={1999},
  volume={5 4},
  pages={401-13}
}
Transmissible spongiform encephalopathies (TSE) are progressive degenerative disorders of the central nervous system. PrP(Sc) is a TSE-specific marker derived from the host-encoded glycoprotein, PrPc. The generation of antibodies to PrP plays an important role in the diagnosis of these diseases. In this study the role of the PrP immunogen and the species being immunized was examined in relation to specific epitopes. Various mammals (mice, hamsters, rabbits and PrP null mice) were immunized with… CONTINUE READING