Immune surveillance against a solid tumor fails because of immunological ignorance.

@article{Ochsenbein1999ImmuneSA,
  title={Immune surveillance against a solid tumor fails because of immunological ignorance.},
  author={Adrian F Ochsenbein and Paul Klenerman and Urs Karrer and Burkhard Ludewig and Marcus Pericin and Hans Hengartner and Rolf Martin Zinkernagel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 5},
  pages={2233-8}
}
Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve as targets for immune effector T cells. Nevertheless, overall immune surveillance against such tumors seems relatively inefficient. We studied immune surveillance against a s.c. sarcoma expressing a characterized viral tumor antigen. Surprisingly, the tumor cells were capable of inducing a protective cytotoxic T cell response if transferred as a single-cell suspension. However, if they… CONTINUE READING