Immune suppressive mechanisms in the tumor microenvironment.

  title={Immune suppressive mechanisms in the tumor microenvironment.},
  author={David H. Munn and Vincenzo Bronte},
  journal={Current opinion in immunology},
Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients by a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells is orchestrated by the activity of a variety of stromal myeloid and lymphoid cells. These often display inducible suppressive mechanisms that are triggered by the same anti-tumor inflammatory response that the immunotherapy intends to create. Therefore, a more comprehensive… CONTINUE READING
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