Immune suppressive activity and lack of T helper differentiation are differentially regulated in natural regulatory T cells.

@article{Zeng2009ImmuneSA,
  title={Immune suppressive activity and lack of T helper differentiation are differentially regulated in natural regulatory T cells.},
  author={Wei-ping Zeng and Chawnshang Chang and Jiann-jyh Lai},
  journal={Journal of immunology},
  year={2009},
  volume={183 6},
  pages={3583-90}
}
The mechanism for controlling Th cytokine expression in natural regulatory T (nTreg) cells is unclear. Here, it was found that under polarizing conditions Foxp3 did not affect Th1 cell, partially inhibited Th17 cell, but greatly inhibited Th2 cell differentiation of conventional CD4 T cells. Under the polarizing conditions, nTreg cells failed to differentiate into Th2 and Th17 cells, but differentiated into IFN-gamma-producing cells. Such Foxp3-transduced CD4 T cells and nTreg cells expressed T… CONTINUE READING

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