Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.

@article{Netea2006ImmuneSO,
  title={Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.},
  author={M. Netea and N. A. Gow and C. Munro and S. Bates and C. Collins and G. Ferwerda and R. Hobson and G. Bertram and H. Hughes and Trees Jansen and L. Jacobs and E. Buurman and K. Gijzen and D. Williams and R. Torensma and A. Mckinnon and D. MacCallum and F. Odds and J. V. D. van der Meer and A. J. Brown and B. Kullberg},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 6},
  pages={
          1642-50
        }
}
The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of beta-glucans and chitin. We demonstrate that cytokine production by human mononuclear cells or murine macrophages was markedly reduced when stimulated by C. albicans mutants defective in mannosylation. Recognition of mannosyl residues was mediated by mannose receptor binding to N-linked mannosyl residues and by… Expand
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