Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

@article{Illing2012ImmuneST,
  title={Immune self-reactivity triggered by drug-modified HLA-peptide repertoire},
  author={P. Illing and J. Vivian and N. Dudek and L. Kostenko and Z. Chen and M. Bharadwaj and J. Miles and L. Kjer-Nielsen and S. Gras and N. Williamson and S. Burrows and A. Purcell and J. Rossjohn and J. McCluskey},
  journal={Nature},
  year={2012},
  volume={486},
  pages={554-558}
}
  • P. Illing, J. Vivian, +11 authors J. McCluskey
  • Published 2012
  • Biology, Medicine
  • Nature
    • Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the antigen-binding cleft, thereby diversifying the repertoire of self-derived and pathogen-derived peptide antigens selected by different HLA allotypes. A growing number of immunologically based drug reactions, including abacavir hypersensitivity syndrome (AHS) and carbamazepine-induced Stevens–Johnson syndrome (SJS), are… CONTINUE READING
    View on Nature
    immunology.ucsf.edu
    505 Citations
    Highly Influencial Citations
    36
    Background Citations
    152
    Methods Citations
    26
    Results Citations
    15
    505 Citations
    Citation Type

    Citation Type

    Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA
    • 59
    Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles
    • 20
    • PDF
    Human leukocyte antigen and idiosyncratic adverse drug reactions.
    • 17
    Pharmacology: A false sense of non-self
    • 5
    Structural Elements Recognized by Abacavir-Induced T Cells
    • 12
    • PDF
    T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells
    • 17
    • PDF
    The role of HLA genes in pharmacogenomics: unravelling HLA associated adverse drug reactions
    • 31
    HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
    • 9
    • PDF
    The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity
    • 4
    • Highly Influenced
    • PDF
    Adverse drug reactions triggered by the common HLA-B*57:01 variant: a molecular docking study
    • 31
    • Highly Influenced

    References

    SHOWING 1-10 OF 32 REFERENCES
    Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity.
    • 274
    • PDF
    Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex.
    • 146
    T cell allorecognition via molecular mimicry.
    • 223
    • PDF
    HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
    • S. Hung, Wen-Hung Chung, +16 authors Y. Chen
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 701
    • PDF
    Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.
    • 190
    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype.
    • 23
    Identification of a dominant self‐ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex
    • 45
    Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    • 1,223
    • PDF
    T-cell allorecognition: a case of mistaken identity or déjà vu?
    • 46
    Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
    • A. Martin, D. Nolan, +9 authors S. Mallal
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2004
    • 420
    • PDF