Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

  title={Immune self-reactivity triggered by drug-modified HLA-peptide repertoire},
  author={P. Illing and J. Vivian and N. Dudek and L. Kostenko and Z. Chen and M. Bharadwaj and J. Miles and L. Kjer-Nielsen and S. Gras and N. Williamson and S. Burrows and A. Purcell and J. Rossjohn and J. McCluskey},
  • P. Illing, J. Vivian, +11 authors J. McCluskey
  • Published 2012
  • Biology, Medicine
  • Nature
  • Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the antigen-binding cleft, thereby diversifying the repertoire of self-derived and pathogen-derived peptide antigens selected by different HLA allotypes. A growing number of immunologically based drug reactions, including abacavir hypersensitivity syndrome (AHS) and carbamazepine-induced Stevens–Johnson syndrome (SJS), are… CONTINUE READING
    505 Citations
    Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA
    • 59
    Human leukocyte antigen and idiosyncratic adverse drug reactions.
    • 17
    Pharmacology: A false sense of non-self
    • 5
    Structural Elements Recognized by Abacavir-Induced T Cells
    • 12
    • PDF
    T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells
    • 17
    • PDF
    The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity
    • 4
    • Highly Influenced
    • PDF
    Adverse drug reactions triggered by the common HLA-B*57:01 variant: a molecular docking study
    • 31
    • Highly Influenced


    T cell allorecognition via molecular mimicry.
    • 223
    • PDF
    HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
    • S. Hung, Wen-Hung Chung, +16 authors Y. Chen
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 701
    • PDF
    Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.
    • 190
    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype.
    • 23
    Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
    • A. Martin, D. Nolan, +9 authors S. Mallal
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2004
    • 420
    • PDF