Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

@article{Illing2012ImmuneST,
  title={Immune self-reactivity triggered by drug-modified HLA-peptide repertoire},
  author={Patricia T. Illing and Julian P. Vivian and Nadine L. Dudek and Lyudmila Kostenko and Zhenjun Chen and Mandvi Bharadwaj and John J Miles and Lars Kjer-Nielsen and Stephanie Gras and Nicholas A. Williamson and Scott R. Burrows and Anthony Wayne Purcell and Jamie Rossjohn and James McCluskey},
  journal={Nature},
  year={2012},
  volume={486},
  pages={554-558}
}
Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the antigen-binding cleft, thereby diversifying the repertoire of self-derived and pathogen-derived peptide antigens selected by different HLA allotypes. A growing number of immunologically based drug reactions, including abacavir hypersensitivity syndrome (AHS) and carbamazepine-induced Stevens–Johnson syndrome (SJS), are… 
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