Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

@article{Illing2012ImmuneST,
  title={Immune self-reactivity triggered by drug-modified HLA-peptide repertoire},
  author={P. Illing and J. Vivian and N. Dudek and L. Kostenko and Z. Chen and M. Bharadwaj and J. Miles and L. Kjer-Nielsen and S. Gras and N. Williamson and S. Burrows and A. Purcell and J. Rossjohn and J. McCluskey},
  journal={Nature},
  year={2012},
  volume={486},
  pages={554-558}
}
  • P. Illing, J. Vivian, +11 authors J. McCluskey
  • Published 2012
  • Biology, Medicine
  • Nature
  • Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the antigen-binding cleft, thereby diversifying the repertoire of self-derived and pathogen-derived peptide antigens selected by different HLA allotypes. A growing number of immunologically based drug reactions, including abacavir hypersensitivity syndrome (AHS) and carbamazepine-induced Stevens–Johnson syndrome (SJS), are… CONTINUE READING
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    References

    SHOWING 1-10 OF 32 REFERENCES
    T cell allorecognition via molecular mimicry.
    • 223
    • PDF
    HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
    • S. Hung, Wen-Hung Chung, +16 authors Y. Chen
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 701
    • PDF
    Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.
    • 190
    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype.
    • 23
    Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
    • A. Martin, D. Nolan, +9 authors S. Mallal
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2004
    • 420
    • PDF