Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy.

@article{Chang2005ImmuneSO,
  title={Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy.},
  author={Chien-Chung Chang and Michael R Campoli and Nicholas P Restifo and Xinhui Wang and Soldano Ferrone},
  journal={Journal of immunology},
  year={2005},
  volume={174 3},
  pages={1462-71}
}
Scanty information is available about the mechanisms underlying HLA class I Ag abnormalities in malignant cells exposed to strong T cell-mediated selective pressure. In this study, we have characterized the molecular defects underlying HLA class I Ag loss in five melanoma cell lines derived from recurrent metastases following initial clinical responses to T cell-based immunotherapy. Point mutations in the translation initiation codon (ATG-->ATA) and in codon 31 (TCA-->TGA) of the beta(2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Epigenetic regulation of immune escape genes in cancer

Cancer Immunology, Immunotherapy • 2006
View 3 Excerpts
Highly Influenced

Defective HLA class I antigen processing machinery in cancer

Cancer Immunology, Immunotherapy • 2018
View 2 Excerpts

Malignant melanoma-The cradle of anti-neoplastic immunotherapy.

Critical reviews in oncology/hematology • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…