Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults.

@article{Treanor2006ImmuneRT,
  title={Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults.},
  author={John Jay Treanor and Hulin Wu and Hua Liang and David J. Topham},
  journal={Vaccine},
  year={2006},
  volume={24 47-48},
  pages={6913-23}
}
The kinetics and frequency of the primary response to human smallpox vaccine was compared to that among subjects re-vaccinated within the last 2 years, or after several decades. Vaccination induced local and systemic reactions that were mildest in the distant cohort and more severe in the primary vaccinees. The timing of IFN-gamma responses was similar in all three groups, but of higher frequency in the primary vaccinees. Responses to vaccinia re-immunization between those immunized <2 years… CONTINUE READING

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