Immune responses to tuberculosis in developing countries: implications for new vaccines

  title={Immune responses to tuberculosis in developing countries: implications for new vaccines},
  author={G. Rook and K. Dheda and Alimuddin Zumla},
  journal={Nature Reviews Immunology},
  • G. Rook, K. Dheda, Alimuddin Zumla
  • Published 2005
  • Medicine
  • Nature Reviews Immunology
  • Tuberculosis is out of control in developing countries, where it is killing millions of people every year. In these areas, the present vaccine — Mycobacterium bovis bacillus Calmette–Guérin (BCG) — is failing. Progressive tuberculosis occurs because the potentially protective T helper 1 (TH1)-cell response is converted to an immunopathological response that fails to eliminate the bacteria. Here, we discuss the data indicating that the problem in developing countries is not a lack of adequate… CONTINUE READING
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