• DOI:10.1038/nri1666
Corpus ID: 9004625

Immune responses to tuberculosis in developing countries: implications for new vaccines

@article{Rook2005ImmuneRT,
  title={Immune responses to tuberculosis in developing countries: implications for new vaccines},
  author={G. Rook and K. Dheda and Alimuddin Zumla},
  journal={Nature Reviews Immunology},
  year={2005},
  volume={5},
  pages={661-667}
}

G. Rook, K. Dheda, Alimuddin Zumla

Published 2005

Medicine

Nature Reviews Immunology

Tuberculosis is out of control in developing countries, where it is killing millions of people every year. In these areas, the present vaccine — Mycobacterium bovis bacillus Calmette–Guérin (BCG) — is failing. Progressive tuberculosis occurs because the potentially protective T helper 1 (TH1)-cell response is converted to an immunopathological response that fails to eliminate the bacteria. Here, we discuss the data indicating that the problem in developing countries is not a lack of adequate… CONTINUE READING

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