Immune responses to tuberculosis in developing countries: implications for new vaccines

@article{Rook2005ImmuneRT,
  title={Immune responses to tuberculosis in developing countries: implications for new vaccines},
  author={G. Rook and K. Dheda and Alimuddin Zumla},
  journal={Nature Reviews Immunology},
  year={2005},
  volume={5},
  pages={661-667}
}
  • G. Rook, K. Dheda, Alimuddin Zumla
  • Published 2005
  • Medicine
  • Nature Reviews Immunology
  • Tuberculosis is out of control in developing countries, where it is killing millions of people every year. In these areas, the present vaccine — Mycobacterium bovis bacillus Calmette–Guérin (BCG) — is failing. Progressive tuberculosis occurs because the potentially protective T helper 1 (TH1)-cell response is converted to an immunopathological response that fails to eliminate the bacteria. Here, we discuss the data indicating that the problem in developing countries is not a lack of adequate… CONTINUE READING
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    References

    SHOWING 1-10 OF 106 REFERENCES
    The success and failure of BCG — implications for a novel tuberculosis vaccine
    • 642
    Prospects for low dose BCG vaccination against tuberculosis.
    • 18
    IL-10-producing T cells suppress immune responses in anergic tuberculosis patients.
    • 419
    • PDF
    Mycobacterial Antigens Exacerbate Disease Manifestations in Mycobacterium tuberculosis-Infected Mice
    • 101
    • PDF