Immune responses to glutamic acid decarboxylase and insulin in patients with gestational diabetes.

@article{Fuechtenbusch2004ImmuneRT,
  title={Immune responses to glutamic acid decarboxylase and insulin in patients with gestational diabetes.},
  author={Martin Fuechtenbusch and Ezio Bonifacio and Vito Lampasona and Annette Knopff and Anette-Gabriele Ziegler},
  journal={Clinical and experimental immunology},
  year={2004},
  volume={135 2},
  pages={
          318-21
        }
}
Pregnancy is a natural state of immunoprotection and tolerance. We studied subjects with gestational diabetes (GDM) to evaluate the influence of pregnancy on the humoral immune response to the autoantigen GAD and to injected insulin. Antibodies against glutamic acid decarboxylase (GADA) subclasses and epitope reactivity were determined in 34 GADA-positive pregnant patients with GDM, in 20 GADA-positive relatives of people with TID and in 25 GADA-positive patients with newly diagnosed TID… CONTINUE READING
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