Immune responses to bovine norovirus-like particles with various adjuvants and analysis of protection in gnotobiotic calves.

@article{Han2006ImmuneRT,
  title={Immune responses to bovine norovirus-like particles with various adjuvants and analysis of protection in gnotobiotic calves.},
  author={Myung Guk Han and Sonia Cheetham and Marli S P Azevedo and Christopher Thomas and Linda J. Saif},
  journal={Vaccine},
  year={2006},
  volume={24 3},
  pages={317-26}
}
We evaluated serum and fecal antibody responses to bovine norovirus (BoNoV) virus-like particles (VLP) and protection against virulent BoNoV in gnotobiotic calves. Calves were vaccinated with two or three doses of VLPs (250 microg/dose) coadministered with oil, mutant E. coli heat-labile toxin (R192G) (mLT) or immunostimulating complexes (ISCOM). Fecal IgA antibody was detected only in calves vaccinated intranasally with VLP+mLT and after challenge, partial protection with delayed, shortened… CONTINUE READING
6 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…