Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain.

Abstract

The nonstructural (NS) proteins of West Nile virus (WNV) have been associated with participation in evasion of host innate immune defenses. In the present study, we characterized immune response to an attenuated WNV strain, which has a P38G substitution in the NS4B protein. The WNV NS4B-P38G mutant induced a lower level of viremia and no lethality in C57BL… (More)
DOI: 10.1016/j.vaccine.2011.04.057

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