Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy.

@article{Ferro2004ImmuneRT,
  title={Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy.},
  author={Valerie A. Ferro and Rosaria Costa and Katharine C. Carter and Michael J A Harvey and Mary M Waterston and Alexander Balfour Mullen and Christian Matschke and Jamie F S Mann and Angela Colston and William H. Stimson},
  journal={Vaccine},
  year={2004},
  volume={22 8},
  pages={1024-31}
}
A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by examining specific antibody levels, antibody subclasses, endocrine ablation and gonadal atrophy. The production of IgG2b antibody provided the best correlation for castration. PLGA was… CONTINUE READING

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