Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence

@article{Fiorentino2022ImmuneRT,
  title={Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence},
  author={David F Fiorentino and Christopher A. Mecoli and Matthew C. Rosen and Lorinda S. Chung and Lisa Christopher‐Stine and Antony Rosen and Livia Casciola-Rosen},
  journal={The Journal of Clinical Investigation},
  year={2022},
  volume={132}
}
BACKGROUND The temporal clustering of a cancer diagnosis with dermatomyositis (DM) onset is strikingly associated with autoantibodies against transcriptional intermediary factor 1-γ (TIF1-γ). Nevertheless, many patients with anti–TIF1-γ antibodies never develop cancer. We investigated whether additional autoantibodies are found in anti–TIF1-γ–positive patients without cancer. METHODS Using a proteomic approach, we defined 10 previously undescribed autoantibody specificities in 5 index anti–TIF1… 
5 Citations

Coexisting autoantibodies against transcription factor Sp4 are associated with decreased cancer risk in dermatomyositis patients with anti-TIF1gamma autoantibodies

Anti-SP4 autoantibodies are enriched in anti-TIF1gamma-positive DM patients without cancer, suggesting that the development of an anti-Sp4 immune response may correlate with a relatively low risk of cancer in these patients.

Coexisting autoantibodies against transcription factor Sp4 are associated with decreased cancer risk in patients with dermatomyositis with anti-TIF1γ autoantibodies

Anti-Sp4 autoantibodies appear to identify a subgroup of anti-TIF1γ-positive DM patients with lower cancer risk and are confirmed by showing that patient sera immunoprecipitated full-length Sp4 protein.

Using autoantibody signatures to define cancer risk in dermatomyositis

Findings indicate that more detailed autoantibody phenotyping at diagnosis might better predict cancer risk and also suggest that diversity and kinetics of the host immune response might influence cancer development.

DERMATOMYOSITIS CLASSIFICATION The 2018

Variations and subclassifications within the same DMSA subtypes are observed: anti-MDA5 dermatomyositis is clinically subcategorized into good, intermediate, and poor prognostic subgroups; concurrent anti-CCAR1 and anti-TIF1-g positivity identify anti- TIF 1-g-positive patient with a lower risk for cancer-associated myositis.

Update on dermatomyositis

DMSA, evidence of prominent IFN1 pathway activation, and risk/severity-associated biomarkers would likely play major roles in future dermatomyositis classification, disease monitoring, and treatment decision.

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