Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imaging.

@article{Wang2010ImmuneRT,
  title={Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imaging.},
  author={Zejing Wang and Rainer Storb and Donghoon Lee and Martin J. Kushmerick and Baocheng Chu and C Berger and Andrea L H Arnett and James Maurice Allen and Jeffrey S. Chamberlain and Stanley R Riddell and Stephen J. Tapscott},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2010},
  volume={18 3},
  pages={
          617-24
        }
}
We previously demonstrated that direct intramuscular injection of rAAV2 or rAAV6 in wild-type dogs resulted in robust T-cell responses to viral capsid proteins, and others have shown that cellular immunity to adeno-associated virus (AAV) capsid proteins coincided with liver toxicity and elimination of transgene expression in a human trial of hemophilia B. Here, we show that the heparin-binding ability of a given AAV serotype does not determine the induction of T-cell responses following… CONTINUE READING

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