Immune responses of mice to inactivated rabies vaccine administered orally: potentiation by Quillaja saponin.

@article{Maharaj1986ImmuneRO,
  title={Immune responses of mice to inactivated rabies vaccine administered orally: potentiation by Quillaja saponin.},
  author={I Maharaj and K J Froh and James B. Campbell},
  journal={Canadian journal of microbiology},
  year={1986},
  volume={32 5},
  pages={414-20}
}
Administered orally, Quillaja saponin markedly potentiated the humoral immune responses of mice fed inactivated rabies vaccine, and significantly increased their resistance to subsequent intracerebral challenge with live rabies virus. Although mean serum neutralizing antibody titres were generally 8- to 16-fold higher when vaccine was given intraperitoneally, orally administered vaccine, with saponin, stimulated production of high protective antibody levels that were maintained for at least 6… CONTINUE READING