Immune responses in newly developed short-lived SAM mice. Selectively impaired T-helper cell activity in in vitro antibody response.

@article{Hosokawa1987ImmuneRI,
  title={Immune responses in newly developed short-lived SAM mice. Selectively impaired T-helper cell activity in in vitro antibody response.},
  author={Tomohide Hosokawa and Masamichi Hosono and Ken-ichi Hanada and Akira Aoike and Keiichi Kawai and Takumi Takeda},
  journal={Immunology},
  year={1987},
  volume={62 3},
  pages={
          425-9
        }
}
New short-lived strains of mice (SAM-P), which have been developed by Takeda et al. (1981), shows a defective antibody response to T dependent (TD) antigen in vitro, as demonstrated in the accompanying paper (see page 419). In the present study, we investigated the cellular site of the defect, using a cell culture system. In this paper, it is demonstrated that T-helper (Th) cell activity for the antibody response to TD antigen is impaired, while other cellular immune responses, e.g. mixed… CONTINUE READING