Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites.

@article{JordnVillegas2011ImmuneRA,
  title={Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites.},
  author={Alejandro Jord{\'a}n-Villegas and Anilza Bonelo Perdomo and Judith E. Epstein and Jes{\'u}s L{\'o}pez and Alejandro E. V. Castellanos and Maria del Rosario Manzano and Miguel A. Hern{\'a}ndez and Liliana Soto and Fabi{\'a}n M{\'e}ndez and Thomas L. Richie and Stephen L Hoffman and Myriam Ar{\'e}valo-Herrera and S{\'o}crates Herrera},
  journal={The American journal of tropical medicine and hygiene},
  year={2011},
  volume={84 2 Suppl},
  pages={43-50}
}
A non-human primate model for the induction of protective immunity against the pre-erythrocytic stages of Plasmodium vivax malaria using radiation-attenuated P. vivax sporozoites may help to characterize protective immune mechanisms and identify novel malaria vaccine candidates. Immune responses and protective efficacy induced by vaccination with irradiated P. vivax sporozoites were evaluated in malaria-naive Aotus monkeys. Three groups of six monkeys received two, five, or ten intravenous… CONTINUE READING
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