Immune response to soluble exoantigens of Plasmodium falciparum may contribute to both pathogenesis and protection in clinical malaria: evidence from a longitudinal, prospective study of semi-immune African children.

@article{Riley1991ImmuneRT,
  title={Immune response to soluble exoantigens of Plasmodium falciparum may contribute to both pathogenesis and protection in clinical malaria: evidence from a longitudinal, prospective study of semi-immune African children.},
  author={Eleanor M. Riley and Palle H. Jakobsen and Stephen J. Allen and Jeremy G. Wheeler and Steve Bennett and S\oren Jepsen and Brian Greenwood},
  journal={European journal of immunology},
  year={1991},
  volume={21 4},
  pages={1019-25}
}
Some soluble exoantigens of Plasmodium have lipopolysaccharide (LPS)-like properties and are believed to contribute to the pathogenesis of acute malaria. We have studied cellular and humoral immune responses to several purified exoantigens of Plasmodium falciparum in a cohort of children and compared these responses with their subsequent susceptibility to malaria infection and clinical disease. We found no evidence that either lymphoproliferative or interferon-gamma (IFN-gamma) responses to… CONTINUE READING

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