Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly(L-lactic acid) microspheres in rats, rabbits and guinea-pigs.

@article{Almeida1993ImmuneRT,
  title={Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly(L-lactic acid) microspheres in rats, rabbits and guinea-pigs.},
  author={Ant{\'o}nio J Almeida and Hazire Oya Alpar and Malcolm R. Brown},
  journal={The Journal of pharmacy and pharmacology},
  year={1993},
  volume={45 3},
  pages={
          198-203
        }
}
Tetanus toxoid was adsorbed onto poly(L-lactic acid) microspheres. Analyses by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and Western blotting suggest that the formulation procedure does not affect the stability or the antigenic properties of the protein. After nasal administration to guinea-pigs, the resulting preparation enhanced the immune response to the tetanus toxoid when compared with the free antigen. The increase in systemic immunoglobulin G titre was almost immediate… CONTINUE READING

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