Immune response to meningococcal serogroup C conjugate vaccine in asplenic individuals.

@article{Balmer2004ImmuneRT,
  title={Immune response to meningococcal serogroup C conjugate vaccine in asplenic individuals.},
  author={Paul Balmer and Michelle Falconer and Paula K. McDonald and Nick Andrews and Emily S. Fuller and Christine A. Riley and Edward B. Kaczmarski and Raymond Borrow},
  journal={Infection and immunity},
  year={2004},
  volume={72 1},
  pages={332-7}
}
Asplenic individuals are known to be at increased risk of infection with encapsulated bacteria. Recent United Kingdom recommendations stated that this at-risk group should receive one dose of the meningococcal serogroup C conjugate (MCC) vaccine. However, the immune response of asplenic individuals to MCC vaccine is unknown. The immune response of asplenics (n = 130) to immunization with the MCC vaccine was investigated. Asplenic individuals had a significantly lower geometric mean titer (GMT… CONTINUE READING