Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial.

Abstract

The objective of this study was to determine the immune response to influenza vaccination in elderly people, using a randomized, double-blind, placebo-controlled trial. Venous blood was taken from 1838 people aged 60 years and older, prior to injection with the influenza vaccine or a placebo. A second blood sample was taken three weeks later. The antibody reaction was measured by comparing the geometric mean titre and the percentage of participants who had a protective antibody titre before and after vaccination and for all sera of each strain. A protective antibody titre was found in 43-68% of those who had received the vaccine, depending on the strain investigated. Patients potentially at risk showed a response similar to the other participants. We conclude that influenza vaccination in elderly people provides a reasonable to good immune response. Research is needed on whether a good immune response decreases the incidence of influenza.

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@article{Govaert1994ImmuneRT, title={Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial.}, author={Tim Govaert and Marc J.W. Sprenger and G J Dinant and Kevin Aretz and Nathalie Masurel and J. Andr{\'e} Knottnerus}, journal={Vaccine}, year={1994}, volume={12 13}, pages={1185-9} }