Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein (gp120).

@article{Pyle1989ImmuneRT,
  title={Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein (gp120).},
  author={Stephen W. Pyle and Bror Morein and Julian W. Bess and Lennart {\AA}kerblom and Peter L. Nara and Stephen M. Nigida and Nicholas William Lerche and W. G. Robey and Peter J. Fischinger and Larry O. Arthur},
  journal={Vaccine},
  year={1989},
  volume={7 5},
  pages={
          465-73
        }
}
In mice, immunostimulatory complexes (ISCOMs) prepared from HIV-1 B external envelope glycoprotein (gp120) induced 10-fold higher antibody titres than gp120 emulsified in depot adjuvant, as measured by enzyme-linked immunosorbent assay (ELISA). Rhesus monkeys immunized with gp120 ISCOMs produced precipitating and virus neutralizing antibody titres equivalent to those seen in HIV-infected chimpanzees and humans. After multiple immunizations with HIV-1 B gp120 ISCOMs, a rhesus monkey developed a… CONTINUE READING

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