Immune response to herpes simplex virus and gamma134.5 deleted HSV vectors.

@article{Broberg2005ImmuneRT,
  title={Immune response to herpes simplex virus and gamma134.5 deleted HSV vectors.},
  author={Eeva K Broberg and Veijo Hukkanen},
  journal={Current gene therapy},
  year={2005},
  volume={5 5},
  pages={
          523-30
        }
}
Herpes simplex virus (HSV) is a large DNA virus with unique properties that can be exploited for in vivo gene therapy. HSV is neurotropic, establishes latency, and has a large transgene capacity. These properties can be utilized in therapy of nervous system diseases. Wild-type HSV and the vectors derived from it induce both innate and acquired immune response. However, HSV is skillful in escaping the host response. It has evoked mechanisms including avoidance of antigen presentation on major… CONTINUE READING

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