Immune response to Nocardia brasiliensis antigens in an experimental model of actinomycetoma in BALB/c mice.

  title={Immune response to Nocardia brasiliensis antigens in an experimental model of actinomycetoma in BALB/c mice.},
  author={Mario C{\'e}sar Salinas-Carmona and Ernesto Torres-Lopez and Andrea I. Ramos and Angel Lic{\'o}n-Trillo and D J Gonz{\'a}lez-Spencer},
  journal={Infection and immunity},
  volume={67 5},
Nine- to twelve-week-old BALB/c mice were injected in footpads with 10(7) CFU of a Nocardia brasiliensis cell suspension. Typical actinomycetoma lesions, characterized by severe local inflammation with abscess and fistula formation, were fully established by day 28 after infection. These changes presented for 90 days, and then tissue repair with scar formation slowly appeared, with complete healing after 150 days of infection. Some animals developed bone destruction in the affected area… CONTINUE READING


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