Immune response of bovines stimulated by synthetic vaccine SBm7462 against Rhipicephalus (Boophilus) microplus.

@article{Patarroyo2009ImmuneRO,
  title={Immune response of bovines stimulated by synthetic vaccine SBm7462 against Rhipicephalus (Boophilus) microplus.},
  author={Joaqu{\'i}n H. Patarroyo and Marlene Isabel Vargas and Cassandra Lee Gonzalez and F. J. Laso Guzm{\'a}n and Olindo Assis Martins-Filho and Luiz Carlos C Afonso and Fabr{\'i}cio Luciani Valente and Ana Paula Peconick and Ana Paula Vieira Marciano and Adriana M. Patarroyo and Sidimar Sossai},
  journal={Veterinary parasitology},
  year={2009},
  volume={166 3-4},
  pages={333-9}
}
Ten-month-old calves Bos taurus taurus were immunized with three doses of SBm7462 with saponin as an adjuvant at 30-day intervals and were evaluated for IgG isotypes, phenotype circulating lymphocytes and changes in the lymph nodes (LN). SBm7462 stimulated the production of predominantly IgG1-isotype IgG antibodies. The lymph nodes exhibited activation at the seventh day after the first immunization, with areas of paracortical and interfollicular hyperplasia and the early formation of germinal… CONTINUE READING

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