Immune response in strain 2 guinea pigs to the syngeneic L2C leukemia.


Immunization of strain 2 guinea pigs with 10(7) syngeneic Ia+ L2C leukemia cells in adjuvant leads to L2C tumor protection. After subsequent challenges with L2C tumor cells, the sera and spleens of the protected guinea pigs had detectable anti-L2C reactivity. The L2C antibody reactivity was preferentially associated with the IgG1 isotype fraction and bound… (More)


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