Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes.

@article{Nabel1996ImmuneRI,
  title={Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes.},
  author={G J Nabel and David Gordon and Douglas K. Bishop and Brian J. Nickoloff and Zhiqiang Yang and Atsushi Aruga and Mark J Cameron and Elizabeth G. Nabel and Alfred E. Chang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 26},
  pages={15388-93}
}
Analysis of the antitumor immune response after gene transfer of a foreign major histocompatibility complex class I protein, HLA-B7, was performed. Ten HLA-B7-negative patients with stage IV melanoma were treated in an effort to stimulate local tumor immunity. Plasmid DNA was detected within treated tumor nodules, and RNA encoding recombinant HLA-B7 or HLA-B7 protein was demonstrated in 9 of 10 patients. T cell migration into treated lesions was observed and tumor-infiltrating lymphocyte… CONTINUE READING

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