• Corpus ID: 20385837

Immune response in hepatitis C Resposta imune na hepatite C

  title={Immune response in hepatitis C Resposta imune na hepatite C},
  author={Luis Jesuino de Oliveira Andrade and Ajax Merc{\^e}s Atta and Maria Atta and Carolina Alves Costa Silva and A D'oliveira and Raymundo Paran{\'a}},
Abstract Autoimmune phenomena are frequent in chronic hepatitis C virus (HCV) infection, and treatment of patients with chronic viral hepatitis creates an essential turning point for therapy of these diseases. The presence of these auto-reactivities in HCV generates clinical overlaps and dilemmas in the correct classification and treatment of such patients. A variety of autoantibodies are often observed in patients with HCV: rheumatoid factor, antinuclear antibodies, antibodies to double… 

Figures from this paper

Seeking markers to distinguish HCV-Infected-autoimmune subjects from uninfected-autoimmune patients
The obtained results showed that both IL6 and BAFF can serve as markers for autoimmunity and/or autoIMmunity resulting from severe HCV infection, whereas, IL10 and TNF-α can be considered as marker forHCV infection in Egypt.


Treatment of autoimmune and extra-hepatic manifestations of HCV infection.
In conclusion, interferon may be appropriate in patients with HCV infection and extrahepatic manifestations linked to immune complex deposition, whereas, in other cases, careful assessment of patients with autoimmune processes is necessary before choosing any treatment strategy.
Autoimmunity and extrahepatic manifestations in hepatitis C virus infection.
Anticardiolipin antibodies in chronic viral hepatitis. Do they have clinical consequences?
  • J. Yuste, J. Prieto
  • Medicine, Biology
    European journal of gastroenterology & hepatology
  • 2003
In conclusion, ACAs are commonly found in patients with chronic viral infection but their pathogenetic role and the mechanisms that stimulate their production have not yet been clarified.
Antimitochondrial antibodies in patients with chronic hepatitis C.
Antimitochondrial antibodies present in patients with chronic hepatitis C do not always recognize the same epitopes as in primary biliary cirrhosis, suggesting that these antibodies may disappear after eradication of HCV.
Anticardiolipin antibodies in chronic hepatitis C: Implication of hepatitis C virus as the cause of the antiphospholipid syndrom
Anticardiolipin antibodies are frequently found in patients with chronic hepatitis C and in these patients they may be implicated in the occurrence of thrombosis and in the development ofThrombocytopenia.
HCV-related autoimmune and neoplastic disorders: the HCV syndrome.
  • C. Ferri, A. Antonelli, A. Zignego
  • Medicine, Biology
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2007
Antimitochondrial antibodies in patients with chronic hepatitis C virus infection: description of 18 cases and review of the literature
A subset of HCV patients with positive AMA who presented an associated SAD, mainly Sjögren's syndrome or systemic sclerosis, together with a high frequency of multiple autoantibodies and an increased prevalence of cirrhosis and neoplasia is described.
Prevalence of ANCA in mixed cryoglobulinemia and chronic hepatitis C virus infection.
Two new target antigens of ANCA have been identified in HCV-associated MC and chronic hepatitis C in this study, adding to various reports on the induction of CG- and BPI-ANCA in chronic infections.
Autoantibodies and hepatitis C virus genotypes in chronic hepatitis C patients in Estonia.
A high prevalence of ANA and SMA can be found in chronic hepatitis C patients, and distribution of the autoantibodies show no differences in the sex groups and between patients infected with different HCV genotypes.
Chronic HCV-related autoimmunity: a consequence of viral persistence and lymphotropism.
The importance of autoimmunity in the evaluation of chronic HCV infected patients is determined to be related to the resistance of CD5+ B cell subpopulation to apoptosis, which has been reported by many to include a wide range of autoantibodies.