Immune response in a murine model of congenital toxoplasmosis: increased susceptibility of pregnant mice and transplacental passage of Toxoplasma gondii are type 2-dependent.

@article{Thouvenin1997ImmuneRI,
  title={Immune response in a murine model of congenital toxoplasmosis: increased susceptibility of pregnant mice and transplacental passage of Toxoplasma gondii are type 2-dependent.},
  author={M Thouvenin and Ermanno Candolfi and Odile Villard and Joshua P. Klein and T T Kien},
  journal={Parassitologia},
  year={1997},
  volume={39 4},
  pages={279-83}
}
We used a model of acquired toxoplasmosis to study the immune response in pregnant BALB/c mice (IL-4+/+) and in pregnant transgenic IL-4-deficient BALB/c mice (IL-4-/-) during acute toxoplasmosis. Female BALB/c mice were infected orally by 20 tissue cysts of the avirulent PRU strain of Toxoplasma gondii on day 11 of pregnancy. Splenocyte cultures were used… CONTINUE READING