Immune response capacity after human splenic autotransplantation: restoration of response to individual pneumococcal vaccine subtypes.

@article{Leemans1999ImmuneRC,
  title={Immune response capacity after human splenic autotransplantation: restoration of response to individual pneumococcal vaccine subtypes.},
  author={Rob Leemans and Willem Lodewijk Manson and J. A. M. Snijder and Jv Smit and H. J. Klasen and T. Hauw The and Wim Timens},
  journal={Annals of surgery},
  year={1999},
  volume={229 2},
  pages={
          279-85
        }
}
OBJECTIVE To evaluate features of general immune function, in particular the restoration of the humoral immune response to pneumococcal capsular polysaccharides, in humans undergoing a spleen autotransplantation after splenectomy because of trauma. SUMMARY BACKGROUND DATA After splenectomy, patients have an increased risk of overwhelming infection or sepsis involving encapsulated bacteria such as pneumococci. The value of human spleen autotransplantation after splenectomy because of trauma… 
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76 Citations
Highly Influential Citations
3
Background Citations
18
Methods Citations
1
Results Citations
2

76 Citations

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Citation Type

Autotransplant of spleen tissue in children with schistosomiasis: evaluation of splenic function after splenosis.
TLDR
Splenosis was efficient in maintaining the filtration splenic function in more than 90% and produced tuftsin inside the range of normality and provided the immunologic splenic response to pneumococcal vaccination in 65% of the patients of this series.
Splenic regeneration following splenectomy and impact on sepsis: a clinical review
TLDR
The role of splenosis and spleen autotransplantation in patients who suffer splenic trauma and their possible protective role on post‐splenectomy sepsis is studied.
After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments
TLDR
According to this study, the presence of only few marginal zone B cells is sufficient to evoke a rise in antibody titres and although antibody titre increases are low, even small rises are most likely clinically relevant.
Recurrent penicillin-resistant pneumococcal sepsis after matched unrelated donor (MUD) transplantation for refractory T cell lymphoma
TLDR
This case illustrates that the choice of prophylactic regimen and the treatment of sepsis in immunocompromised patients remain difficult and challenging issues.
Antibody Response of Autogenous Splenic Tissue Implanted in the Abdominal Cavity of Mice
TLDR
The T cell-dependent antibody response in implanted splenic tissues is as efficient as in the intact spleen, with no difference between the graft sites studied.
Cellular and serological changes in the peripheral blood of splenectomized and spleen autotransplanted mice.
Distribution of peripheral blood cells in mice after splenectomy or autotransplantation
TLDR
In conclusion, spleen autotransplantation has some beneficial effects, including clearing erythrocytes and preserving the phagocytic activity of neutrophils in peripheral blood.
Single segment of spleen autotransplantation, after splenectomy for trauma, can restore splenic functions
TLDR
It is suggested that splenic autotransplantation is able to restore an adequate hemocatheretic activity as well as recover the immunological deficit after splenectomy.
Splenic tissue autotransplantation in rabbits: no restoration of host defense
TLDR
The low quantity and poor quality of the regenerated splenic tissue contribute to the inferior immunoprotective ability of animals autotransplanted with one-third of the original spleen, suggesting that the regeneration spleen cannot compensate for the immunological function of theOriginal one, especially host resistance to infection.
Bacterial phagocytosis by macrophage of autogenous splenic implant.
TLDR
The present results suggest that autogenous splenic implants in the greater omentum of the rat acquire the macro- and microscopic architecture of a normal spleen, with reduced dimensions, and preserve bacterial phagocyte function.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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