Immune response and tolerance during chronic hepatitis B virus infection

@article{Bertoletti2007ImmuneRA,
  title={Immune response and tolerance during chronic hepatitis B virus infection},
  author={Antonio Bertoletti and Adam J Gehring},
  journal={Hepatology Research},
  year={2007},
  volume={37}
}
The hepatitis B virus (HBV) is a hepatotropic non‐cytopathic DNA virus that despite the presence of an effective prophylactic vaccine is estimated to infect 300 million people, with a particularly high prevalence in Asia and Africa. It causes liver diseases that vary greatly in severity from person to person. Some subjects control infection efficiently and clear the virus from the bloodstream either without clinically evident liver disease or with an acute inflammation of the liver (acute… Expand
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A new strategy based on T cell receptor (TCR) gene transfer to reconstitute the defective antiviral immunity of chronic patients and its inherently self-limiting toxicity suggests potential for application in other HBV-related pathologies is developed. Expand
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Hepatitis B virus (HBV) was identified and characterized after the discovery of the Australia antigen by Blumberg and colleagues in 1965. The Australia antigen, now designated hepatitis B surface… Expand
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TLDR
The current knowledge regarding the interactions among HBV, HDV, and the infected target cell is summarized and the dependence of HDV on HBV activity and possible future therapeutic approaches are discussed. Expand
Viral Hepatitis in Solid Organ Transplant Recipients
  • J. Levitsky, K. Doucette
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2009
TLDR
This chapter will focus primarily on the epidemiology, transmission, clinical presentation and management of the primary hepatitis viruses: HBV, HCV, HDV and HEV, following solid organ transplantation. Expand
Chronic hepatitis B virus in young adults: the need for new approaches to
TLDR
The immunological analysis of HBV in young people and the role of a dedicated clinic is reported, making the case for earlier intervention to achieve effective immune control leading to better outcomes. Expand
Modulation of Apoptotic Signaling by the Hepatitis B Virus X Protein
TLDR
This review will summarize reports in which the impact of HBx expression on cellular apoptotic pathways has been analyzed and suggest mechanisms that could link HBx modulation of apoptosis pathways to the development of HBV-associated HCC. Expand
Chronic hepatitis B virus in young adults: the need for new approaches to management
TLDR
The immunological analysis of HBV in young people and the role of a dedicated clinic is reported, making the case for earlier intervention to achieve effective immune control leading to better outcomes. Expand
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TLDR
The immune pathological features of HBV infection from early life to adulthood are reviewed and the concept of a generic immune tolerant state in young people is challenged and the potential to consider earlier therapeutic intervention in HBV-infected young patients to achieve effective immune control leading to better outcomes is addressed. Expand
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