Immune response and tolerance during chronic hepatitis B virus infection

@article{Bertoletti2007ImmuneRA,
  title={Immune response and tolerance during chronic hepatitis B virus infection},
  author={Antonio Bertoletti and Adam J. Gehring},
  journal={Hepatology Research},
  year={2007},
  volume={37}
}
The hepatitis B virus (HBV) is a hepatotropic non‐cytopathic DNA virus that despite the presence of an effective prophylactic vaccine is estimated to infect 300 million people, with a particularly high prevalence in Asia and Africa. It causes liver diseases that vary greatly in severity from person to person. Some subjects control infection efficiently and clear the virus from the bloodstream either without clinically evident liver disease or with an acute inflammation of the liver (acute… 
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This chapter will focus primarily on the epidemiology, transmission, clinical presentation and management of the primary hepatitis viruses: HBV, HCV, HDV and HEV, following solid organ transplantation.
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The immunological analysis of HBV in young people and the role of a dedicated clinic is reported, making the case for earlier intervention to achieve effective immune control leading to better outcomes.
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