Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice.

@article{Klein1977ImmuneRA,
  title={Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice.},
  author={Roswitha J. Klein and Alvin E. Friedman-Kien and A A Fondak and Elena Buimovici-Klein},
  journal={Infection and immunity},
  year={1977},
  volume={16 3},
  pages={842-8}
}
Treatment of herpes simplex virus (HSV)-infected hairless mice with a 2% phosphonoacetic acid (PAA) ointment prevented the appearance of virus-induced skin lesions and subsequent central nervous system (CNS) involvement. Treatment started 24 h after infection significantly reduced the intensity of the skin lesions and also prevented CNS involvement. After four to six applications of PAA ointment, a moderate skin erythemia developed, followed by scaling and complete healing 7 days after… CONTINUE READING