Immune regulatory functions of human beta-defensin-2 in odontoblast-like cells.

  title={Immune regulatory functions of human beta-defensin-2 in odontoblast-like cells.},
  author={H Dommisch and J Winter and C Willebrand and J{\"o}rg Eberhard and S\oeren Jepsen},
  journal={International endodontic journal},
  volume={40 4},
AIM To investigate the effects of human beta-defensins on the expression of genes involved in the host immune response of the dental pulp. METHODOLOGY Human odontoblast-like cells were cultured in Dulbecco's modified Eagle's medium. Cells were stimulated by recombinant human beta-defensins (rhBDs) up to 4 h. RNA was extracted followed by cDNA synthesis (oligo-(dT)-primer). Samples were analysed by real-time polymerase chain reaction (PCR) technology. Genes of interest were: human beta… CONTINUE READING


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