Immune regulation within the central nervous system.

  title={Immune regulation within the central nervous system.},
  author={Baoguo Xiao and Hans Link},
  journal={Journal of the neurological sciences},
  volume={157 1},
The brain constitutes an environment that is specifically designed to accommodate, regulate and shape immune responses. On one hand, the central nervous system (CNS) has traditionally been regarded as an immunologically privileged organ, owing to local tissue barrier and immunosuppressive microenvironment. On the other hand, activated microglia and astrocytes express MHC and adhesion/costimulatory molecules, release reactive oxygen intermediates and cytokines, and participate in local immune… CONTINUE READING


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