Immune regulation of central nervous system functions: from sickness responses to pathological pain

@article{Watkins2005ImmuneRO,
  title={Immune regulation of central nervous system functions: from sickness responses to pathological pain},
  author={Linda R. Watkins and Steven F. Maier},
  journal={Journal of Internal Medicine},
  year={2005},
  volume={257}
}
Classically, the central nervous system (CNS) and the immune system are thought to operate independently of each other. This simplistic view has been corrected in recent years, first with the recognition that the brain dynamically modulates the immune system, and later with the reverse; that is, that the immune system modulates the CNS as well. The evidence that the immune system regulates CNS functions is first reviewed. This immune‐to‐brain communication pathway triggers the production of a… 
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