Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.

@article{Overbergh2006ImmuneRO,
  title={Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.},
  author={Lut Overbergh and Katinka Stoffels and Mark Waer and Annemieke Verstuyf and R Bouillon and Chantal Mathieu},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 9},
  pages={
          3566-74
        }
}
CONTEXT 25-Hydroxyvitamin D can be activated to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma (IFNgamma). In pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)(2)D(3) and hypercalcemia. OBJECTIVE The aim of this study was to elucidate the intracellular pathways used by the immune system to tightly regulate 1,25(OH)(2)D(3… CONTINUE READING