Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

@inproceedings{Li2014ImmuneRB,
  title={Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers},
  author={Huili Li and Katherine B. Chiappinelli and Angela A. Guzzetta and Hariharan Easwaran and Ray-Whay Chiu Yen and Rajita Vatapalli and Michael J. Topper and Jianjun Luo and Roisin M Connolly and Nilofer Saba Azad and Vered Stearns and Drew Mark Pardoll and Nancy E. Davidson and Peter A. Jones and Dennis J. Slamon and Stephen B. Baylin and Cynthia A. Zahnow and Nita Ahuja},
  booktitle={Oncotarget},
  year={2014}
}
Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidine (AZA). Gene Set Enrichment Analysis demonstrated significant enrichment for immunomodulatory pathways in all three cancers (14.4-31.3%) including interferon signaling, antigen processing and… CONTINUE READING
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