Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity

@article{Gall2019ImmuneRI,
  title={Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity},
  author={Margaret G. Gall and Hui Emma Zhang and Quintin Lee and Christopher J. Jolly and Geoffrey W McCaughan and Adam J. L. Cook and Ben Roediger and Mark D. Gorrell},
  journal={Scientific Reports},
  year={2019},
  volume={9}
}
The ubiquitous intracellular protease dipeptidyl peptidase 9 (DPP9) has roles in antigen presentation and B cell signaling. To investigate the importance of DPP9 in immune regeneration, primary and secondary chimeric mice were created in irradiated recipients using fetal liver cells and adult bone marrow cells, respectively, using wild-type (WT) and DPP9 gene-knockin (DPP9S729A) enzyme-inactive mice. Immune cell reconstitution was assessed at 6 and 16 weeks post-transplant. Primary chimeric… 
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