Immune-refractory cancers and their little helpers--an extended role for immunetolerogenic MHC molecules HLA-G and HLA-E?

@article{Wischhusen2007ImmunerefractoryCA,
  title={Immune-refractory cancers and their little helpers--an extended role for immunetolerogenic MHC molecules HLA-G and HLA-E?},
  author={J{\"o}rg Wischhusen and Anne Waschbisch and Heinz Wiendl},
  journal={Seminars in cancer biology},
  year={2007},
  volume={17 6},
  pages={459-68}
}
There is strong evidence to support a role for non-classical MHC class I (class Ib) molecules, most notably HLA-E and HLA-G in tumour immune escape. In this article, we summarize the current knowledge on their expression, regulation and functional relevance in various malignancies, particularly brain tumours. Special emphasis is devoted to the phenomenon that these tolerogenic molecules are expressed by non-transformed cells that are found in close neighborhood to tumour cells representing… CONTINUE READING

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