Immune reconstitution after cord blood transplantation: peculiarities, clinical implications and management strategies.

@article{Lucchini2015ImmuneRA,
  title={Immune reconstitution after cord blood transplantation: peculiarities, clinical implications and management strategies.},
  author={Giovanna Lucchini and M L Perales and Paul A. Veys},
  journal={Cytotherapy},
  year={2015},
  volume={17 6},
  pages={711-722}
}
Umbilical cord blood (UCB) is now widely used as an alternative hematopoietic stem cell source for patients lacking closely matched related or unrelated adult donors. UCB transplantation has traditionally been associated with delayed engraftment, poor immune reconstitution and consequent increased risk of infection. More recent clinical studies, however, suggest that conditioning regimens and in particular the omission of in vivo T-cell depletion may play a crucial role in post-transplant T… CONTINUE READING
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