Immune recognition of transplacentally acquired lymphoid allografts selects for increased major histocompatibility polymorphism.


The extreme polymorphism of mammalian major histocompatibility (MHC) Class I and Class II alleles has been attributed to inbreeding avoidance, heterozygote advantage and pathogen driven selection for rare MHC alleles. However, MHC alleles can be classified into a limited number of allele supertypes based on the specificity of their peptide binding grooves… (More)
DOI: 10.1016/j.mehy.2011.05.005