Immune reactivity in cattle with ocular squamous cell carcinoma after intralesional BCG immunotherapy

@article{Klein1986ImmuneRI,
  title={Immune reactivity in cattle with ocular squamous cell carcinoma after intralesional BCG immunotherapy},
  author={Wim R. Klein and Peter A. Steerenberg and Fred G. J. Poelma and Elly v. d. Wiel and V P M G Rutten and Wim Misdorp and Wim H. de Jong and Elis Joost Ruitenberg},
  journal={Cancer Immunology, Immunotherapy},
  year={1986},
  volume={22},
  pages={87-94}
}
Lymphocyte stimulation with Con A and specific immune reactivity to BCG (antibody formation to BCG and DTH reaction to PPD) were determined in BCG-treated, surgically treated and untreated cows with ocular squamous cell carcinoma. In tumor-bearing cows the Con A-induced proliferation of lymphocytes was reduced when compared to healthy controls. This suppression consisted of a reduced blastogenic response to Con A of lymphocytes from tumor-bearing cows, and the presence of a factor in the sera… CONTINUE READING